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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: J Immunol. 2011 Dec 5;188(2):541–547. doi: 10.4049/jimmunol.1101498

Figure 1. H4R negatively regulates EAE severity and BBB permeability.

Figure 1

Clinical score (A) and severity of CNS lesions (B) in WT (■, n=32) and H4RKO (□, n=30) mice were compared following immunization with MOG35-55-CFA-PTX. The significance of the differences between the clinical courses of disease was calculated by regression analysis and best-fit curve is shown. In (B), the significance of differences observed at d30 post-immunization was determined using the Mann-Whitney test (** p<0.01; *** p<0.001). (C) The significance of differences in BBB permeability indices of WT and H4RKO mice across the early acute phase of disease was assessed by regression analyses (n=8 for each strain at each time point).