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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Epilepsia. 2011 Nov 29;53(1):168–176. doi: 10.1111/j.1528-1167.2011.03337.x

Figure 2. Action potential bursts evoked in TLE neurons by synaptic stimulation are profoundly suppressed by adenosine.

Figure 2

Stimulation of mEC layer III consistently evoked bursts of APs in mEC layer II neurons in TLE (A, left trace). In contrast, only a single AP could be evoked from control neurons (B, left trace). The profound inhibitory effects of adenosine in TLE neurons (500 nM, 1 μM and 100 μM) are shown on the top panel of A. In B, the same concentrations were applied to control neurons, but had little effect. Dashed lines represent -60 mV. In C, bar chart shows the enhanced concentration dependent effect of adenosine on TLE neurons compared to control. Bars represent means ± S.E.M. # P < 0.005, t P < 0.001.