Table 1.
Subject characteristics by OSA status
| OSA (+) | OSA (−) | p value | |
|---|---|---|---|
| Number (males) | 9 (4) | 15 (10) | 0.386 |
| Age, mean (years) | 14.2 (1.66) | 14.6 (1.72) | 0.577 |
| Age, range (years) | 12–17 | 12–18 | |
| BMI z-score | 1.30 (1.03) | 1.44 (1.30) | 0.785 |
| Sleep study indices | |||
| Apnea-hypopnea index | 13.5 (11.9) | 0.78 (0.86) | <0.001 |
| AHI, range | 5.9–40.4 | 0–2.5 | |
| REM O2 saturation nadir | 93.5 (5.68) | 95.8 (1.66) | 0.154 |
| Non-REM O2 saturation nadir | 92.9 (4.9) | 93.9 (2.4) | 0.520 |
| Mean O2 saturation | 98. 5 (1.5) | 98.5 (0.5) | 0.880 |
| Insulin resistance | |||
| HOMA-IR | 8.7 (3.9) | 9.0 (7.0) | 0.171 |
| Insulin (fasting, IU/mL) | 79.9 (122) | 37.8 (39.2) | 0.210 |
| Glucose (fasting, mg/dL) | 101.7 (3.6) | 95.4 (9.7) | 0.917 |
| Systemic inflammation | |||
| hsCRP (mg/L) | |||
| Evening hsCRP | 1.70 (2.68) | 1.88 (2.10) | 0.860 |
| Morning hsCRP | 1.69 (2.49) | 2.03 (2.60) | 0.882 |
| Change hsCRP (absolute) | −0.002 (0.31) | 0.15 (1.03) | 0.343 |
| Change hsCRP (percent) | 12.7 (27.0) | 4.0 (21.3) | 0.140 |
| hsIL-6 (pg/mL) | |||
| Evening hsIL-6 | 1.84 (1.73) | 2.29 (2.29) | 0.643 |
| Morning hsIL-6 | 1.69 (1.10) | 1.61 (1.27) | 0.882 |
| Change hsIL-6 (absolute) | −0.15 (0.96) | −0.68 (1.41) | 0.343 |
| Change hsIL-6 (percent) | 48.6 (126.3) | −8.8 (41.5) | 0.140 |
| hsTNF-a (pg/mL) | |||
| Evening hsTNF-α | 0.94 (0.46) | 0.90 (0.48) | 0.850 |
| Morning hsTNF-α | 0.99 (0.24) | 0.98 (0.10) | 0.968 |
| Change hsTNF-α (absolute) | 0.0.54 (0.10) | 0.085 (0.10) | 0.706 |
| Change hsTNF-α (percent) | 12.2 (30.2) | 9.3 (10.0) | 0.772 |
Mean values are listed with standard deviations in parentheses. Items in bold are statistically significant (p<0.05)
OSA obstructive sleep apnea, BMI body mass index, AHI apnea-hypopnea index, REM rapid eye movement, HOMA-IR homeostasis model for insulin resistance, hsCRP high-sensitivity C-reactive protein, hsIL-6 high-sensitivity IL-6