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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Epilepsia. 2011 Dec 9;53(1):134–146. doi: 10.1111/j.1528-1167.2011.03338.x

Figure 2.

Figure 2

SPD prevents lithium-pilocarpine SE-induced cognitive decline. Summarized results representing the average time (Mean ± SEM) required for rats to find the escape platform (latency) of rats trained in the Morris water maze. Trial days one through five consisted of four training sessions with a hidden platform and days six and seven consisted of four trials per day to find the visible platform using the acquired spatial map. There was a progressive decrease in escape latencies over the training days in all 3 groups. Animals in the naïve and drug-treated group (Pilo + SPD) learned to navigate quickly using the visual cues and there was no statistically significant difference between the two groups in their ability to find the escape platform. Pilocarpine-treated SE animals had a significantly higher escape latency and performed poorly in acquisition and retention of spatial memory, in comparison to the naïve control group and the SPD group *, p < 0.05, One-Way ANOVA with Newman-Keuls multiple comparison test.