Table 1.
SPD anticonvulsant activity (in comparison to valnoctamide-VCD) in various mouse (ip) & rat (po) models for epilepsy
| Anticonvulsant test | SPD-ED50 (mg/kg) |
95% Confidence interval (CI- mg/kg) |
VCD-ED50 (mg/kg) |
|---|---|---|---|
| Frings Audiogenic Seizures | 20 | 18-22 | -a |
| Maximal electroshock seizure (mice-MES) |
71 | 55-90 | 58 |
| Maximal electroshock seizure (rats- MES) |
ip: 20 po:29 |
15-27 1 -53 |
po: 29 |
| Metrazol-induced seizure (mice-scMet) |
62 | 47-71 | 32 |
| Metrazol-induced seizure (rats-scMet) |
18 | 13–25 | 54 |
| Picrotoxin-induced seizure (mice-Pic) |
17 | 9 – 28 | - |
| Bicuculine-induced seizure (mice-Bic) |
94 | 87 – 103 | - |
| Corneal kindled mouse | 39 | 31-45 | - |
| Hippocampal kindled rats | 19 | 13-28 | ~40 |
| 6 Hz-32mA (mice) | 27 | 24 – 30 | 37 |
| Mice-Neurotoxicity (TD50) | 88 | 81-95 | 77 |
| Rat-Neurotoxicity (TD50) | ip: 49 po: 131 |
43-55 94-175 |
po:58 |
-a
Not tested