Table 2.
Comparative efficacy of SPD, VCD and several prototypical AEDs against benzodiazepine-resistant convulsive seizures in the lithium-pilocarpine model of SE
| Compound Tested |
ED50 - mg/kg (95%CI) | |
|---|---|---|
| 0 min post SE onset | 30 min post SE onset |
|
| SPD | 8/8 protected at 65 mg/kg | 84 (62-103) |
| Valnoctamide (VCD) | 8/8 protected at 65 mg/kg | 0/8 at 80 mg/kg |
| Clonazepam* | 1.3 (0.6-2.5) | >40 mg/kg |
| Carbamazepine* | 45 (38 -52) | 50 (44-56) |
| Diazepam* | 3.0 (1.6 -4.4) | 0/8 at 10 mg/kg |
| Valproic acid* | 366 (23-575) | 0/8 at 300 mg/kg |
| Phenobarbital* | 31 (18-46) | 0/8 at 40 mg/kg |
*
Data on file with the Anticonvulsant Screening Project, NINDS, NIH. The 0 min post SE onset data are given only as comparators.