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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Free Radic Biol Med. 2011 Nov 10;52(2):497–506. doi: 10.1016/j.freeradbiomed.2011.11.001

Figure 5. Mito-CP attenuates cisplatin-induced inflammation.

Figure 5

Cisplatin significantly increased mRNA expression of pro-inflammatory chemokines MCP-1 (Panel A), MIP-1α and MIP-2 (Panel B), myeloperoxidase staining and activity (Panels C and D), adhesion molecule ICAM-1 and pro-inflammatory cytokine TNF-α mRNA expressions (Panels E and F) in the kidneys 72 h following its administration to mice, indicating enhanced inflammatory response. These changes could be largely prevented by treatment with Mito-CP. Results are mean±S.E.M. of 6–16/group. *P<0.05 Vehicle; #P<0.05 vs. Cisplatin.