Figure 5.
TUNEL staining in the infarct border zone of C57 (A) and MRL (B) hearts 1 day post-MI (n = 6 in each group). Arrows point to TUNEL-positive nuclei. Dotted lines denote the approximate infarct boundary. An asterisk marks the injured region. A representative image of remote LV myocardium is shown in panel C. The number of TUNEL-positive nuclei closely associated with myocytes was significantly higher in C57 hearts than MRL hearts (P = 0.001) (D). There were no statistically significant differences between LG/J hearts (n = 4) and the other groups. Bar = 50 μm. ***, P = 0.001.