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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Hepatology. 2011 Dec 29;55(2):437–446. doi: 10.1002/hep.24708

Figure 8. Proposed role of lipin-1 signaling in the development of alcoholic fatty liver.

Figure 8

Chronic ethanol feeding downregulates hepatic AMPK signaling. This inhibition promotes SREBP-1 activity, leading to increased total lipin-1, and favors production of cytosolic lipin-1, resulting in increased PAP activity and TG synthesis in mouse livers. We further speculate that ethanol affects lipin-1’s role in regulating FA oxidation. The net consequence of these changes is to promote hepatic steatosis. AMPK, AMP-activated protein kinase; ER, endoplasmic reticulum; SREBP-1, sterol regulatory element binding protein1. PAP, phosphatidate phosphatase type; PPAR, peroxisome proliferator-activated receptor; PGC-1α, PPARγ co-activator-alpha; TG, triglyceride.