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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: J Immunol. 2011 Dec 7;188(2):569–577. doi: 10.4049/jimmunol.1101446

Figure 3. CD4+ T cells are required for the induction of the secondary, but not primary IgG anti-MCPS response to intact M1883.

Figure 3

BALB/c mice (7 per group) were injected i.p. either with a depleting anti-CD4+ mAb (clone GK.1.5) or polyclonal rat IgG (“Control”) [0.5 mg per mouse]. Both Ab-injected mice and athymic nude mice (BALB/c background) were then immunized, 1 day later, i.p. with 2 × 108 CFU of heat-inactivated intact M1883 in saline, and boosted 21 days later in the absence of Ab. Serum titers of Ag-specific IgG were measured by ELISA. Significance (*) p≤0.05 between “Control” versus and-CD4 mAb-injected mice or athymic nude mice.