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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: J Immunol. 2011 Dec 7;188(2):569–577. doi: 10.4049/jimmunol.1101446

Figure 5. CD40 ligand-dependent costimulation is critical for the induction of the secondary, but not primary, IgG anti-MCPS response to M1883.

Figure 5

BALB/c mice (7 per group) were injected i.p. with either anti-CD40L mAb (clone MR1) or polyclonal hamster IgG (“Control”) [0.3 mg per mouse]. Mice were then immunized, 1 day later, i.p. with 2 × 108 CFU of heat- inactivated intact M1883 in saline and boosted 21 days later. Serum titers of Ag-specific IgG were determined by ELISA. Significance (*) p≤0.05 between “Control” versus anti-CD40L-injected mice.