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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: J Immunol. 2011 Dec 7;188(2):569–577. doi: 10.4049/jimmunol.1101446

Figure 6. Endogenous TLR4, but not TLR2 or MyD88, signaling is critical for induction of peak primary and secondary serum titers of MCPS-specific IgG in response to M1883, but is not critical for secondary boosting.

Figure 6

(A) C3H/HeJ(Tlr4Lps-d) and C3H/HeOuJ (control mice), or (B) TLR2−/− or (C) MyD88−/− mice (same group of control C57BL//6 mice used for both “B” and “C”) [7 per group] were immunized i.p. with 2 × 108 CFU of heat-inactivated intact M1883 in saline and boosted on day 21 and 35. Serum titers of MCPS-specific IgM, IgG, and IgG isotypes were determined by ELISA from sera obtained on the indicated days.