Table 2.
Selected Baseline Characteristics in Relation to Hormone Therapy in 71,237 Women Eligible for the Analysis of All-Cause Mortality
| Hormone Therapy
|
|||||
|---|---|---|---|---|---|
| Never* n=17874 |
Former* n=11426 |
Current* n=37912 |
|||
| Freq. (%) | Freq. (%) | p-valuea | Freq. (%) | p-valuea | |
| Risk Factors | |||||
| BMI† | <.0001 | <.0001 | |||
| <18 | 294 (1.6) | 162 (1.4) | 426 (1.1) | ||
| 18–22.5 | 4648 (26.0) | 3029 (26.5) | 12121 (32.0) | ||
| 22.5–25 | 3747 (21.0) | 2521 (22.0) | 9054 (23.9) | ||
| 25–30 | 4708 (26.3) | 3203 (28.0) | 9916 (26.2) | ||
| >30 | 2940 (16.5) | 1659 (14.5) | 4819 (12.7) | ||
| Other/Unknown | 1537 (8.6) | 852 (7.5) | 1576 (4.2) | ||
| Smoking | <.0001 | <.0001 | |||
| Never | 11088 (62.0) | 6660 (58.3) | 22054 (58.2) | ||
| Former | 5463 (30.6) | 4074 (35.7) | 13731 (36.2) | ||
| Current | 1323 (7.4) | 692 (6.1) | 2127 (5.6) | ||
| Alcohol | <.0001 | <.0001 | |||
| Never | 4222 (23.6) | 2335 (20.4) | 6082 (16.0) | ||
| Former | 2655 (14.9) | 1687 (14.8) | 4854 (12.8) | ||
| Current, <20 g/d | 8446 (47.3) | 5650 (49.5) | 21710 (57.3) | ||
| Current, ≥20 g/d | 1499 (8.4) | 1064 (9.3) | 3745(9.9) | ||
| Unknown | 1052 (5.9) | 690 (6.0) | 1516 (4.0) | ||
| Medical History | |||||
| Prior heart attack | 0.0003 | <.0001 | |||
| No | 17252 (96.5) | 10991 (96.2) | 37194 (98.1) | ||
| Yes | 504 (2.8) | 389 (3.4) | 590 (1.6) | ||
| Unknown | 118 (0.7) | 46 (0.4) | 128 (0.3) | ||
| Prior stroke | 0.001 | <.0001 | |||
| No | 17343 (97.0) | 11066 (96.8) | 37271 (98.3) | ||
| Yes | 413 (2.3) | 314 (2.8) | 513 (1.4) | ||
| Unknown | 118 (0.7) | 46 (0.4) | 128 (0.3) | ||
| Prior cancer | <.0001 | <.0001 | |||
| No | 14184 (79.4) | 8027 (70.3) | 34533 (91.1) | ||
| Yes | 3690 (20.6) | 3399 (29.7) | 3379 (8.9) | ||
| Prior diabetes | 0.0005 | <.0001 | |||
| No | 16793 (94.0) | 10842 (94.9) | 36708 (96.8) | ||
| Yes | 963 (5.4) | 538 (4.7) | 1076 (2.8) | ||
| Unknown | 118 (0.7) | 46 (0.4) | 128 (0.3) | ||
| Mortality | |||||
| Death | 0.46 | <.0001 | |||
| No | 14606 (81.7) | 9376 (82.1) | 35292 (93.1) | ||
| Yes | 3268 (18.3) | 2050 (17.9) | 2620 (6.9) | ||
| Death from IHD | 0.005 | <.0001 | |||
| No | 17219 (96.4) | 11076 (97.0) | 37508 (99.0) | ||
| Yes | 653 (3.7) | 347 (3.0) | 391 (1.0) | ||
| Hormone Therapy
|
|||||
|---|---|---|---|---|---|
| Never* | Former* | Current* | |||
| Mean ± SD | p-valuea | Mean ± SD | p-valuea | ||
| Behavioral Factors** | |||||
| Physical Activity‡, hrs/wk/yr | 3.5 ± 4.3 | 3.4 ± 4.1 | 0.33 | 3.7 ± 4.1 | <.0001 |
| Daily dietary calories, kcal | 1498.5 ± 535.5 | 1484.4 ± 508.8 | 0.03 | 1534.3 ± 518.7 | <.0001 |
| Dietary calories from fat, kcal/d | 480.4 ± 237.2 | 466.6 ± 226.1 | <.0001 | 483.2 ± 229.8 | 0.21 |
| Dietary calories from protein, kcal/d | 239.1 ± 95.2 | 237.2 ± 91.7 | 0.11 | 242.7 ± 91.2 | <.0001 |
| Dietary cholesterol, mg/d | 191.1 ± 114.1 | 186.9 ± 110.9 | 0.003 | 188.1 ± 104.8 | 0.005 |
*
Data presented as No. (%) for categorical variables, or mean ± SD for continuous variables.
a
p-value: compare former user vs. non-users and current uses vs. non-users, calculated using chi-square for categorical variables, t-test for continuous variables.
†
BMI: body mass index, calculated as weight in kilograms divided by height in meters squared.
‡
Physical activity: combination of strenuous and moderate activities in past three years
**
Computed on subjects with known values.