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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Am J Kidney Dis. 2011 Oct 5;59(2):284–292. doi: 10.1053/j.ajkd.2011.07.024

Figure 3.

Figure 3

Relationship of clustering of ANGPTL4 with effacement of podocyte foot processes. Immunogold electron microscopy of NPHS2-ANGPTL4 transgenic rats revealed a progression from (left) intact foot processes (FP) with gold particles just entering the glomerular basement membrane (GBM) in young rats, (middle) to partial effacement with GBM gold particle clusters opposite to effaced foot processes (EFP) reaching up to the endothelial (ENDO) surface (usually noted starting age 3 months), and finally (right) diffuse effacement with dense gold particle clusters in the GBM usually noted by age 5 months. Scale bars denote 0.2 μm. Abbreviation: TG, transgenic. Reproduced from Clement et al9.