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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Int J Impot Res. 2011 Oct 6;24(2):69–76. doi: 10.1038/ijir.2011.47

Figure 5.

Figure 5

Enhanced cGMP levels in mice tissue treated with PnTx2-6 were contained by L-NAME and ω-conotoxin GVIA. The first and second bars showed basal and cGMP levels in the presence of PnTx2-6 without EFS. From third to the last bar, experiments were performed in the presence of EFS (8Hz). Cavernosal tissue from diabetic and non-diabetic mice treated with toxin showed increased cGMP levels compared to non-treated. L-NAME (10−4 M) and ω-conotoxin GVIA (10−6 M) suppressed cGMP levels increased by PnTx2-6 incubation. These results point to participation of N-type Ca+2 channels in the improved relaxation mediated by NO/cGMP pathway due to PnTx2-6 (n=4 per group, p<0.05).