Table 2.
Comparison between finasteride and dutasteride (referenced in text).
| Finasteride | Dutasteride | |
|---|---|---|
| Family | Steroidal 5α-RI (4-azasteroid) | Steroidal 5α-RI (4-azasteroid) |
|
| ||
| IC50 for 5α-R1, 2 and 3 (nM) | 360, 69, 17.4 | 7, 6, 0.33 |
|
| ||
| FDA-approved clinical uses | Male androgenic alopecia Benign prostatic enlargement |
Benign prostatic enlargement |
|
| ||
| Clinical dose | 1 mg daily for male androgenic alopecia 5 mg daily for benign prostatic enlargement |
0.5 mg daily |
|
| ||
| Half-life (T 1/2) | 6–8 hours | 5 weeks |
|
| ||
| Suppression of DHT | ↓Serum DHT by 71% | ↓Serum DHT by 95% |
|
| ||
| ↓Intraprostatic DHT by 85% | ↓Intraprostatic DHT by 97–99% | |