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. Author manuscript; available in PMC: 2012 Dec 9.
Published in final edited form as: Mol Cell. 2011 Dec 9;44(5):828–840. doi: 10.1016/j.molcel.2011.11.009

Figure 6. Identified iPAR-CLIP binding sites are functional in vivo.

Figure 6

(a,d) Reporter constructs containing a gld-1 promoter fused to GFP::Histone 2B and lin-28 or cpg-2 3′UTRs with unaltered or mutated versions of the GLD-1 binding motif were introduced into C. elegans. (b,c,e,f) Mutation of the GLD-1 binding motif leads to de-repression of reporter constructs in the meiotic region of the germline where GLD-1 is expressed.