Table 1.
Terminal left ventricular functional parameters of male ob-ZSF1 rats treated with vehicle, TRC120038, or candesartan.
| Left Ventricular functional Parameters | Vehicle 1 mL/kg | TRC120038 11.8 mg/kg, bid, po | Candesartan 0.3 mg/kg, od, po |
|---|---|---|---|
| Mean ± SEM (n = 8) | Mean ± SEM (n = 11) | Mean ± SEM (n = 10) | |
| Heart rate (bpm) | 264.1 ± 9.1 | 274.1 ± 14.1 | 266.4 ± 17.1 |
| Minimum volume (μL) | 80.8 ± 14.7 | 38.0 ± 8.4∗,∗∗ | 82.0 ± 11.8 |
| End systolic volume (μL) | 97.2 ± 14.1 | 48.0 ± 11.1∗,∗∗ | 91.9 ± 10.8 |
| End diastolic volume (μL) | 139.7 ± 19.5 | 101.0 ± 12.8∗,∗∗ | 144.0 ± 13.5 |
| End systolic pressure (mmHg) | 180.4 ± 10.3 | 133.0 ± 11.9* | 149.2 ± 11.7* |
| End diastolic pressure (mmHg) | 13.7 ± 3.1 | 7.5 ± 1.0* | 7.2 ± 0.8* |
| Stroke volume (μL) | 65.4 ± 7.2 | 73.0 ± 8.7 | 72.4 ± 4.2 |
| Ejection fraction (%) | 46.7 ± 4.8 | 69.4 ± 5.0∗,∗∗ | 48.7 ± 3.6 |
| Cardiac output (μL/min) | 17143.6 ± 1815.0 | 20298.4 ± 2920.0 | 19018.4 ± 1241.0 |
| Arterial elastance (mmHg/μL) | 3.0 ± 0.4 | 2.1 ± 0.3* | 2.1 ± 0.2* |
| Tau_w (msec) | 15.9 ± 1.0 | 12.2 ± 0.5* | 12.8 ± 0.6* |
| Total peripheral resistance index | 5.4 ± 0.8 | 3.6 ± 0.6* | 3.9 ± 0.4* |
| Augmentation Index | 0.4 ± 0.04 | 0.3 ± 0.04* | 0.4 ± 0.05 |
*P ≤ 0.05 versus vehicle; **P ≤ 0.05 versus candesartan by Student's t-test.
Data represent mean ± SEM (standard error mean).