Table 1.
Demographic Variables and Clinical Characteristics
| DVPX (N = 11) | RISP (N= 11) | HC (N = 14) | RISP vs. DVPX | ||
|---|---|---|---|---|---|
| Variable | Mean (SD) | Mean (SD) | Mean (SD) | F (2, 33), p | t(20), p |
| Age in Years (Age Range: 10 – 19) | 12.09 (2.47) | 12.64 (1.69) | 14.14 (3.01) | 2.29, p = .117 | .61, p = .552 |
| Estimated IQa (IQ Range: 70–139) | 96.17 (18.2) | 94.67 (9.7) | 106.5 (12.0) | 2.96, p = .07 | .45, p = .774 |
| YMRS pre | 25.5 (7.6) | 27.2 (6.6) | .9 (1.5) | 88.54, p < .001 | .54, p = .595 |
| YMRS post | 12.6 (9.3) | 11.6 (11.7) | 1.1 (1.9) | 7.67, p = .002 | .22, p = .826 |
| YMRS change | 12.9 (9.4) | 15.5 (9.4) | −0.2 (1.8) | 16.73, p < .001 | .66, p = .517 |
| CDRS-R pre | 39.6 (15.3) | 45.7 (14.9) | 19.5 (2.5) | 17.04, p < .001 | .96, p = .348 |
| CDRS-R post | 30.0 (7.7) | 26.3 (6.8) | 18.6 (1.4) | 8.93, p = .001 | 1.21, p = .242 |
| CDRS-R change | 9.6 (11.2) | 19.4 (14.1) | .9 (1.5) | 5.35, p = .01 | 1.83, p = .083 |
| Variable | N (%) | N (%) | N (%) | X2(df = 2), p | Fisher’s Exact p |
| Sex | |||||
| Male | 9 (82%) | 7 (64%) | 7 (50%) | 2.70, p = .259 | p = .635 |
| Female | 2 (18%) | 4 (36%) | 7 (50%) | ||
| Handedness | |||||
| Left | 2 (18%) | 0 (0%) | 0 (0%) | 4.83, p =.090 | p = .476 |
| Right | 9 (82%) | 14 (100%) | 14 (100%) | ||
| Race Composition | |||||
| Caucasian | 7 (64%) | 7 (64%) | 8 (57%) | .152, p = .927 | p = 1.0 |
| Other | 4 (36%) | 4 (36%) | 6 (43%) |
Legend: DVPX=Divalproex; RISP=Risperidone; HC=Healthy Control; YMRS=Young Mania Rating Scale; CDRS-R=Child Depression Rating Scale-Revised; SES=socioeconomic status.
a
Estimated with Wechsler Abbreviated Scale of Intelligence (WASI; Matrix Reasoning and Vocabulary Subtests).