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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Oct 16;18(11):1235–1243. doi: 10.1038/nsmb.2154

Figure 3. Mass spectra showing the loss of protection from deuterium exchange in 2F5m F100BS and I100FS for peptides from (a) the CDRH3 and (b) the CDRL2 after 10 min in deuterated buffer.

Figure 3

For each protein, four conditions are shown: undeuterated form, UN; 2F5 alone; 2F5 in the presence of MPER in solution (+MPER); and 2F5 in the presence of liposomes containing embedded MPER (+MPER in lipo). The data shown in panel a for wt 2F5 are the same as the data shown in Fig. 2c. The bimodal, multiple population phenomena can also be observed at the other exchange timepoints (Fig 2b).