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. Author manuscript; available in PMC: 2012 Dec 13.

Published in final edited form as: Circulation. 2011 Nov 14;124(24):2690–2701. doi: 10.1161/CIRCULATIONAHA.111.028498

SOCS3 cKO mice developed cardiac dysfunction under acute pressure overload. A, Echocardiography before (Pre TAC) and 10 days after TAC (Post TAC) (8 weeks old, female, n=6 and 7, respectively). The changes in echo data before and after TAC were compared between the two groups using repeated measure ANOVA (*p<0.05). As a control, sham operated mice (n=5 in each group) were also examined at 10 days. PG; pressure gradient between right and left carotid arteries measured 10 days post TAC. LV/TL; LV weight and tibia length ratio. B, Activation of STAT3, ERK1/2 and AKT signaling in the heart 10 days after TAC. **p<0.05 comparing SOCS3 cKO with WT.

SOCS3 cKO mice developed cardiac dysfunction under acute pressure overload. A, Echocardiography before (Pre TAC) and 10 days after TAC (Post TAC) (8 weeks old, female, n=6 and 7, respectively). The changes in echo data before and after TAC were compared between the two groups using repeated measure ANOVA (*p<0.05). As a control, sham operated mice (n=5 in each group) were also examined at 10 days. PG; pressure gradient between right and left carotid arteries measured 10 days post TAC. LV/TL; LV weight and tibia length ratio. B, Activation of STAT3, ERK1/2 and AKT signaling in the heart 10 days after TAC. **p<0.05 comparing SOCS3 cKO with WT.