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Link between Wee1 and Mus81. A. Lack of Wee1 hiperactivates Cdk2 that deregulates DNA replication and produces DNA aberrant structures that are substrate of Mus81/Eme1. B. Wee1 kinase regulates the Mus81/Eme1 endonuclease complex, either indirectly through inhibition of cyclin-dependent kinase Cdk2, which could be an activator of Mus81, or directly through phosphorylation and inhibition of Mus81/Eme1 complex.
