Table 2.

Immunohistochemistry findings in small cell carcinoma of the urinary bladder.

Antibody	No of studies	% of positives staining (mean)
Neuroendocrine markers
NSE[2,9,11,23]	4	25-100% (88.5%)
Synaptophysin[2,11,9]	3	66.6-76% (72.4%)
Serotonin[23]	1	78%
Chromogranin[2,9,11,17]	4	22-89% (50%)
Epithelial markers
Cytokeratin[2,23]	2	70-77% (75%)
EMA[2]	1	77.7%
CK7[24]	1	59%
CAM 5.2[2,11,9]	3	47-66.6% (41%)
Other markers
S-100 protein[23]	1	40%
TTF1[24,25]	2	39-50% (40%)
EGFR[9,26]	2	27-36% (28.6%)
C-KIT[9,27]	2	22-27% (27%)
CD44v6[11]	1	7%
PDGFR[28]	1 case report	+

Abbreviations. NSE = neuron specific enolase; EMA = epithelial membrane antigen; CK7 = cytokeratine 7; EGFR = epidermal growth factor receptor; PDGFR = platelet derived growth factor