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. 2012 Jan 9;7(1):e28784. doi: 10.1371/journal.pone.0028784

Figure 7. Curcumin reduces intra-hepatic lipid content and lipogenic gene expression.

Figure 7

(A) Curcumin supplementation reduced liver weight in HFD fed mice (n = 4 for all 3 groups). (B) MRI shows that curcumin supplementation reduced intra-hepatic lipid content (n = 4 for all 3 groups). (C) Curcumin supplementation reduced the expression of TxNIP, ChREBP and SREBP-1c in liver of HFD fed mice (A representative blot, n = 3). (D) Curcumin supplementation reduced liver ChREBP, SREBP-1c, L-PK and TxNIP mRNA expression in HFD fed mice (n = 3). (E) The ChREBP-LUC reporter plasmid construct (3 µg) were transfected into HepG2 cells for 24 h, followed by a 20 h serum starvation and a 4 h curcumin (20 µM) treatment. The data are presented as mean ± SEM (n = 3). *; p<0.05; **, p<0.01. F. Curcumin supplementation blocked the stimulatory effect of HFD on S6K1 phosphorylation in the liver.