Figure 6. M. tuberculosis H37Rv RNA altered human monocyte's ability to control M. tuberculosis infection.

CFUs were determined for human monocytes infected with M. tuberculosis H37Rv and incubated for four days in the presence of 1 µg/ml of M. tuberculosis H37Rv CF, purified RNA (gpRNA), or purified RNA digested with RNaseV1 (gpRNA+RNaseV1). The presence of CF or gpRNA resulted in a significant increase in CFUs as compared to the untreated infected monocytes (Control). Data represent the mean ± SEM of 3 replicates of the same experiment (*p<0.03).