Table 1. Eligibility criteria for the S-CAST study.

Inclusion Criteria

Potential participants must:

be 18 years of age or older be able to understand the study, and having understood, provide written informed consent in English meet DSM-IV-TR diagnostic criteria for current (within the last 12 months) dependence for cocaine or methamphetamine have smoked cigarettes for at least 3 months, currently smoking ≥ 7 cigarettes/day, and have a measured exhaled CO level > 8 ppm have an interest in quitting smoking and a willingness to comply with all study procedures and medication instructions be enrolled in outpatient treatment at a participating CTP and scheduled to attend at least one treatment session per week for at least 10 weeks after randomization if female and of child bearing potential, agree to use an acceptable method of birth control during the study

Exclusion Criteria

Potential participants must not:

meet DSM-IV-TR diagnostic criteria for current (within the past month) dependence for alcohol or sedatives or have a physiological dependence on alcohol or sedatives requiring medical detoxificatio have an Axis-I psychiatric condition that would make study participation unsafe or which would make treatment compliance difficult meet DSM-IV-TR criteria for current (12 months) bipolar disorder or current (12 months) or lifetime anorexia nervosa or bulimia be seeking/receiving treatment for opiate-agonist replacement therapy (e.g., methadone, buprenorphine), naltrexone, or for detoxification only have a history of a seizure disorder have experienced a closed head trauma with >30 minutes loss of consciousness within the past 12 months have a potentially life-threatening or progressive medical illness other than addiction that may compromise participant safety or study conduct use/have used other smoking-cessation counseling programs or medication treatments currently, or within the last 30 days have a known or suspected hypersensitivity to bupropion, nicotine, or menthol (the nicotine inhaler contains menthol) be pregnant or breastfeeding have used any of the following medications within 14 days of randomization: monoamine oxidase (MAO) inhibitors, antimalarials, tramadol, theophylline, systemic steroids, quinolones, bupropion, any investigational drug, or any drug with known potential for toxicity to a major organ system (e.g., isoniazid, methotrexate) and/or have used sedating antihistamines within 7 days of randomization. be taking medications which may produce potentially dangerous interactions with bupropion XL be anyone who, in the judgment of the investigator, would not be expected to complete the study protocol have used electronic cigarettes or tobacco products, other than cigarettes, in the week before consent be a significant suicidal/homicidal risk be seeking and likely to enter residential/inpatient treatment within 10 weeks have all stimulant-positive UDS results during screening/baseline