Table 3.
Protein | Position | Virus
|
Pathogenicity
|
|||||
---|---|---|---|---|---|---|---|---|
6KS0185 | H4N8/Australia | H4N8/Osaka | H4N6/Shiga | Low | High | Ref.b | ||
PB2 | 271 | T | T | T | T | T | A | a) |
482 | R | R | K | K | K | R | b) | |
627 | E | E | E | E | E | K | c) | |
701 | D | D | D | D | D | N | d), e) | |
714 | S | S | S | S | S | R | d) | |
PB1 | 13 | P | P | P | P | P | d) | |
538 | D | D | D | D | D | G | d) | |
678 | S | N | S | S | N | d) | ||
PB1-F2 | 66 | N | N | N | N | N | S | f) |
PA | 97 | T | T | T | C | T | I | g) |
550 | L | L | L | L | I | L | h) | |
615 | R | R | K | K | K | N | d) | |
M1 | 139 | T | T | T | T | T | A | b) |
NS1 | 92 | D | D | (ND)c | D | D | E | i) |
C-terminus | GSEV | ESEV | (ND) | ESEV | RSEV | ESEV | j), k) |
The protein sequences of 6KS0185, A/red-necked stint/Australia/1/04 (H4N8), A/duck/Osaka/1/05 (H4N8), and A/duck/Shiga/8/04 (H4N6) were compared with the molecular determinants of viral pathogenicity. The amino acids matched to the determinants for high pathogenicity are highlighted by gray shading.
References: a) Bussey et al., 2010; b) Brown and Bailly, 1999; c) Subbarao et al., 1993; d) Gabriel et al., 2005; e) Li et al., 2005; f) Conenello et al., 2007; g) Song et al., 2009; h) Rolling et al., 2009; i) Seo et al., 2002; j) Jackson et al., 2008; k) Obenauer et al., 2006.
Not determined.