Table 1.
Human viruses studied using Drosophila melanogaster.
| Virus | Involvement in human disease | Experimental systems used | References |
|---|---|---|---|
| Dengue virus (DENV) | Dengue fever, hemorrhagic fever | Drosophila cell culture (infected) | Mukherjee and Hanley, 2010, Sessions et al., 2009 |
| Epstein–Barr virus (EBV) | Infectious mononucleosis, various cancers, autoimmune disease | Live Drosophila (transgenic) | Adamson et al. (2005) |
| Hepatitis B virus (HBV) | Hepatitis B, liver cancer | Drosophila cell culture (transfected) | Wang et al. (1998) |
| Human immunodeficiency virus 1 (HIV-1) | Acquired immune deficiency syndrome (AIDS) | Drosophila cell culture (transfected), live Drosophila (transgenic) | Battaglia et al., 2001, Brighty and Rosenberg, 1994, Chan et al., 2002, Chaudhuri et al., 2007, Ivey-Hoyle and Rosenberg, 1990, Lee et al., 2005, Leulier et al., 2003, Ponti et al., 2008 |
| Human cytomegalovirus (HCMV) | Birth defects, mononucleosis, severe complications in immunocompromised individuals | Live Drosophila (transgenic) | Steinberg et al. (2008) |
| Influenza A virus | Flu pandemics, pneumonia, respiratory failure | Drosophila cell culture (infected), live Drosophila (transgenic) | Adamson et al., 2011, Chou et al., 2007, Hao et al., 2008, Lam et al., 2010, Li et al., 2004 |
| SARS coronavirus (SARS-CoV) | Severe acute respiratory syndrome (SARS) | Live Drosophila (transgenic) | Chan et al., 2007, Chan et al., 2009; Wong et al. (2005) |
| Simian vacuolating virus 40 (SV40) | Possibly oncogenic | Live Drosophila (transgenic) | Kotadia et al. (2008) |
| Sindbis virus (SINV) | Sindbis fever, Pogosta disease | Drosophila cell culture (infected), live Drosophila (infected) | Avadhanula et al., 2009, Brackney et al., 2010, Galiana-Arnoux et al., 2006, Mudiganti et al., 2006, Mudiganti et al., 2010, Rose et al., 2011, Sabin et al., 2009, Saleh et al., 2009 |
| Vaccinia virus (VACV) | Fever, rash, used as vaccine to protect against smallpox | Drosophila cell culture (infected), live Drosophila (infected, transgenic) | Chou et al., 2007, Li et al., 2004, Moser et al., 2010, Sabin et al., 2009 |
| Vesicular stomatitis virus (VSV) | Flu-like symptoms in humans, usually infects livestock | Drosophila cell culture (infected), live Drosophila (infected) | Cherry, 2009, Mueller et al., 2010, Sabin et al., 2009, Shelly et al., 2009 |
| West Nile virus (WNV) | West Nile fever, encephalitis | Drosophila cell culture (infected), live Drosophila (infected) | Brackney et al., 2010, Chotkowski et al., 2008, Glaser and Meola, 2010 |