(A) Hepatic gene expression in chow-fed L-FoxO1 and L-FoxO1,O3,O4 mice. Values are shown relative to same-strain littermate controls (n=6–8). (B) Hepatic gene expression from mice sacrificed on postnatal day 2 (P2) (n=6). (C) Hepatic gene expression during a fasting-refeeding time course (n=5–6). Mice were fasted up to 24 hours, starting at 8pm, or fasted 24 hours then refed chow for 0.25 or 4.25 hours. Black and white boxes at the bottom of each graph indicate the light/dark cycle. (D) Comparison of gene expression on chow and WTD (n=6–7). *P<0.05, **P < 0.01, ***P < 0.001, by Student's t-tests (A–C) or two-way analysis of variance (D). Data are presented as mean ± S.E.M.