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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Eur J Pharmacol. 2011 Nov 3;674(2-3):337–344. doi: 10.1016/j.ejphar.2011.10.033

Figure 1.

Figure 1

Effects of MDMA, HMMA and methamphetamine on dialysate 5-HT concentrations measured in blood specimens obtained from drug-naïve catheterized rats. Blood specimens were withdrawn and dialyzed in vitro as described under Materials and Methods. Test drugs were dissolved in Ringer's solution to yield the appropriate concentration and added directly to blood specimens via reverse dialysis at 0 min. Top panels show time-course 5-HT data (pg/5 μl) whereas bottom panels depict mean drug effects at each dose (% basal). Data are mean ± S.E.M. for N=5 rats/group. * P < 0.05 compared to 0 dose group for a given drug; # P < 0.05 compared to HMMA and methamphetamine at a given dose.