TABLE.
Changes in lesion depth and integrated mineral loss (ΔZ) from partially-demineralized artificial caries-like lesions following remineralization with Mineral Trioxide Aggregate in the presence or absence of biomimetic analogs.
| Parameter | Time period |
“b” control† -adhesive (N=10) |
“c” control† -no adhesive (N=10) |
“d” biomimetic‡ -adhesive (N=10) |
“e” biomimetic‡ -no adhesive (N=10) |
|---|---|---|---|---|---|
| Lesion depth (µm) |
“a” baseline* | 286.0 ± 16.6 X | 279.1 ± 7.3 X | 280.4 ± 14.0 X | 288.5 ± 17.8 X |
| 2 weeks | 272.2 ± 7.7 | 250.7 ± 16.2 | 165.1 ± 16.5 | 146.1 ± 10.2 | |
| 4 weeks | 253.9 ± 32.0 | 237.5 ± 20.8 | 143.0 ± 14.6 | 75.6 ± 14.6 | |
| 6 weeks** | 231.8 ± 36.7 A,1 | 206.0 ± 10.7 A,2 | 106.5 ± 14.1 B,1 | 69.5 ± 30.1 B,2 | |
| ΔZ (µm.vol%) |
“a” baseline* | 4923.5 ± 283.8 Y | 4908.2 ± 130.0 Y | 4943.3 ± 220.0 Y | 4732.4 ± 240.3 Y |
| 2 weeks | 4647.4 ± 347.9 | 4526.4 ± 400.9 | 2565.0 ± 146.7 | 1631.1 ± 224.9 | |
| 4 weeks | 4555.5 ± 399.6 | 3779.6 ± 220.2 | 808.6 ± 138.2 | 358.7 ± 124.9 | |
| 6 weeks | 4354.7 ± 303.4 | 3563.7 ± 328.0 | 554.5 ± 164.8 | 213.4 ± 177.7 | |
| Remineralization efficacy at 6 weeks*** |
11.9 ± 7.2 a | 27.3 ± 7.4 a | 88.7 ± 3.5 b | 98.5 ± 0.6 b | |
“a”, “b”, “c”, “d” and “e” correspond to the designations adopted for Figures 2–4. Values are means ± standard deviations.
Control – Remineralization with MTA only in simulated body fluid (SBF).
Biomimetic – Remineralization with biomimetic analogs-containing MTA in SBF.
For each parameter (lesion depth or ΔZ), values with the same upper letter superscript are not statistically significant (p > 0.05).
The first letter superscript represents “control” vs “biomimetic” remineralization; values with different letter superscripts are statistically significant (p < 0.05). The second numeral superscript represents “adhesive” vs “no adhesive”. Values with different numerical superscripts are statistically significant (p < 0.05).
Remineralization efficacy = [(ΔZ baseline − ΔZ 6 weeks)/ΔZ baseline*100%], where ΔZ represents the integrated mineral loss from the artificial caries-like dentin. Values with different lower letter superscripts are statistically significant (p < 0.05).