Table 4.

Odds ratios (95% CI) for Any Depression (Minor or Major) or Antidepressant Use and Major Depression or Antidepressant Use Among Pregnant Women with Pre-existing Only (N = 131), Pregnancy-Related Only (N=347) and Pre-existing with superimposed preeclampsia (N = 287) Versus Those with No Hypertension (N = 1633) – Using Multiple Imputation

	Any depression (minor of major) or antidepressant usea N = 327 (13.6%)			Major depression or antidepressant useb N = 235 (9.8%)
	Pre-existing HTN only	Pregnancy- related HTN	Both pre-existing & superimposed preeclampsia	Pre-existing HTN only	Pregnancy- related HTN	Both pre-existing & superimposed preeclampsia
Unadjusted	2.27h (1.48 – 3.49)	1.15 (0.82 – 1.62)	1.66g (1.19 – 2.32)	2.07g (1.26 – 3.40)	1.29 (0.88 – 1.90)	1.70** (1.16 – 2.49)
Adjusted For
Demographicsb	2.29h (1.47 – 3.57)	1.12 (0.79 – 1.59)	1.62g (1.15 – 2.29)	2.00g (1.20 – 3.33)	1.24 (0.84 – 1.84)	1.64* (1.11 – 2.43)
Demographics +chronic conditionsd	1.98h (1.25 – 3.13)	1.04 (0.73 – 1.49)	1.39 (0.97 – 2.00)	1.76f (1.04 – 2.98)	1.18 (0.80 – 1.76)	1.43 (0.95 – 2.16)
Demographics + chronic conditionsd + current smoking	1.94g (1.22 – 3.08)	1.04 (0.72 – 1.49)	1.38 (0.96 – 1.99)	1.71g (1.01 – 2.91)	1.18 (0.79 – 1.76)	1.43 (0.95 – 2.16)
Demographics + chronic conditionsd + current smoking + pregnancy characteristicse	1.93f (1.08 – 3.09)	0.92 (0.59 – 1.43)	1.42 (0.93 – 2.16)	1.62 (0.88 – 2.98)	1.06 (0.65 – 1.73)	1.66* (1.04 – 2.65)

^aMajor depression, minor depression, or antidepressant use vs. no depression

^bMajor depression or antidepressant use vs. no major depression

^cDemographic characteristics: maternal age at depression screen (years), marital status (married or partnered, single), non-white race/ethnicity, education (some college, high school or less), employment (yes, no)

^dNumber of chronic conditions out of 10

^ePregnancy characteristics: prior pregnancy (yes, no), gestational week at depression screen (weeks), ≥1 prior pregnancy complication (yes, no)

^fp <0.05

^gp <0.01

^hp <0.001