Scheme 4.
Cross-coupling reactions and N,O-bond cleavage of amine 11.
Conditions: (a) 12{7,8}, [PdCl2(dppf)]•CH2Cl2 (5 mol %), CsF, toluene, 110 °C (b) 12{4}, Pd(OAc)2 (10 mol %), (±)-BINAP (12 mol %), Cs2CO3, toluene, 100 °C
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