Table 3.

Association of rs6505162 and rs4919510 with recurrence-free survival stratified by host characteristics

Variables	Stratum	Genotypea	rs6505162			rs4919510
			Event/totalc	HR (95% CI)b	P value	Event/total	HR (95% CI)	P value
Overall		WW	74/242	1(reference)		47/122	1(reference)
		WV + VV	60/166	1.59(1.08–2.36)	0.019	86/285	0.61(0.41–0.92)	0.017
Age
	Younger (<61)	WW	42/117	1(reference)		26/55	1(reference)
		WV + VV	33/83	1.33(0.76–2.32)	0.319	49/145	0.44(0.25–0.79)	0.005
	Older(≥ 61)	WW	32/125	1(reference)		21/67	1(reference)
		WV + VV	27/83	2.05(1.07–3.93)	0.031	37/140	0.77(0.41–1.46)	0.427
				P for interaction	0.387		P for interaction	0.361
Gender
	Male	WW	38/131	1(reference)		28/65	1(reference)
		WV + VV	38/99	2.17(1.26–3.74)	0.005	48/165	0.47(0.27–0.81)	0.006
	Female	WW	36/111	1(reference)		19/57	1(reference)
		WV + VV	22/67	1.12(0.60–2.13)	0.717	38/120	0.94(0.50–1.79)	0.856
				P for interaction	0.401		P for interaction	0.092
Educational level
	Up to high school	WW	27/114	1(reference)		17/49	1(reference)
		WV + VV	27/64	2.06(1.14–3.74)	0.017	36/128	0.66(0.35–1.24)	0.194
	College or higher	WW	36/98	1(reference)		25/55	1(reference)
		WV + VV	27/73	1.51(0.87–2.60)	0.144	38/116	0.52(0.30–0.91)	0.022
				P for interaction	0.469		P for interaction	0.302
Body mass index (BMI)
	BMI <22.7	WW	36/123	1(reference)		23/64	1(reference)
		WV + VV	24/77	0.83(0.43–1.63)	0.593	36/135	0.49(0.25–0.97)	0.041
	BMI ≥ 22.7	WW	38/117	1(reference)		24/56	1(reference)
		WV + VV	34/83	2.60(1.47–4.58)	0.001	48/144	0.61(0.35–1.06)	0.078
				P for interaction	0.096		P for interaction	0.741
Smoking status
	Never smoker	WW	55/170	1(reference)		32/91	1(reference)
		WV + VV	43/119	1.44(0.92–2.27)	0.113	65/197	0.69(0.43–1.11)	0.125
	Ever smoker	WW	19/72	1(reference)		15/31	1(reference)
		WV + VV	17/47	2.70(1.15–6.31)	0.022	21/88	0.34(0.13–0.88)	0.027
				P for interaction	0.401		P for interaction	0.206
Drinking status
	Never drinker	WW	65/218	1(reference)		40/112	1(reference)
		WV + VV	50/147	1.50(0.98–2.30)	0.064	74/252	0.64(0.41–1.00)	0.051
	Ever drinker	WW	9/24	1(reference)		7/10	1(reference)
		WV + VV	10/19	7.88(1.24–50.07)	0.029	12/33	0.46(0.11–1.90)	0.283
				P for interaction	0.591		P for interaction	0.636
Chemotherapy
	No	WW	15/54	1(reference)		5/18	1(reference)
		WV + VV	11/35	1.96(0.79–4.83)	0.144	21/71	1.57(0.48–5.07)	0.454
	Yes	WW	59/188	1(reference)		42/104	1(reference)
		WV + VV	49/131	1.58(1.01–2.49)	0.046	65/214	0.48(0.30–0.75)	0.001
				P for interaction	0.852		P for interaction	0.072
Tumor position
	Colon	WW	34/116	1(reference)		24/60	1(reference)
		WV + VV	30/76	1.09(0.59–2.00)	0.785	40/132	0.60(0.32–1.12)	0.108
	Rectum	WW	40/126	1(reference)		23/62	1(reference)
		WV + VV	30/90	1.91(1.06–3.42)	0.030	46/153	0.66(0.37–1.19)	0.169
				P for interaction	0.254		P for interaction	0.538
Tumor differentiation
	Poor and Moderate	WW	57/184	1(reference)		41/94	1(reference)
		WV + VV	50/124	1.81(1.16–2.82)	0.009	65/213	0.54(0.35–0.85)	0.008
	Well	WW	17/58	1(reference)		6/28	1(reference)
		WV + VV	10/42	0.88(0.32–2.44)	0.808	21/72	1.65(0.46–5.91)	0.440
				P for interaction	0.253		P for interaction	0.218
Tumor stage
	Stage 0–2	WW	32/148	1(reference)		23/76	1(reference)
		WV + VV	24/110	1.09(0.62–1.92)	0.772	32/181	0.51(0.28–0.92)	0.026
	Stage 3–4	WW	42/94	1(reference)		24/46	1(reference)
		WV + VV	36/56	1.87(0.99–3.53)	0.053	54/104	0.65(0.35–1.22)	0.183
				P for interaction	0.091		P for interaction	0.476

Note: The significant P values (≤0.05) are in bold.

^aWW, homozygous wild-type genotype; WV heterozygous genotype; VV, homozygous variant genotype; Dom, dominant model

^bAdjusted for age, gender, education level, BMI, smoking status, drinking status, chemotherapy, tumor position, tumor differentiation, tumor stage, where appropriate.

^cEvent: recurrence and/or death.