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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Mol Genet Metab. 2011 Oct 19;105(1):64–72. doi: 10.1016/j.ymgme.2011.10.004

Figure 2. Inward rectification properties of Kir channels.

Figure 2

Current amplitude in response to membrane voltage is shown by representative current-voltage (I–V) relationships of Kir channels with both strong inward rectifiers (A. aqua trace), or mild inward rectifiers illustrated (A. dark red trace). Current in the negative direction (inward current) is indicated by a downward arrow and current in the positive direction is the outward current. For strong inward rectifiers, the outward current is completely blocked by intracellular factors affecting the I–V relationship as compared to the persistent outward current demonstrated by mild inward rectifiers. B) I–V relationship model of a mildly inward rectifier channel (B. dark red trace, as in A.) showing predicted changes in both inward and outward current due to either a gain-of-function (B. green trace) or loss-of-function (B. red trace) due to genetic mutation(s).