Table 2.

Putative antagonistically pleiotropic disease alleles.

Disease	Gene; Variation	Putative Benefit
Triosephosphate Isomerase Deficiency	TPI Gene: point mutations.	Reduction in oxidative stress.
Tay Sachs	HEXA: missense mutations.	Protection against tuberculosis.
Hemachromatosis	HFE Gene: many point mutation.	Better iron absorption, increased resistance to typhoid fever and tuberculosis
Phenylketonuria	PKU: missense mutation.	Lower probability of miscarriage
Leukemia	PTNP11: various expression level mutations.	Lower probability of hepatocellular carcinoma
Schizophrenia	Chromosomal regions 6p22-p24 and 11q21-22.	Higher relative fertility (in unaffected relatives).
Cancer	TNFRSF11B Gene; Various Polymorphisms	Increased Bone Density in Females

These diseases have been proposed to have antagonistic pleiotropic effects in their etiology, but the evidence is suggestive and preliminary.