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Serum titration (bioavailability) of AB-1. Balb/c mice were gavaged with one dose (100 mg/kg), with blood collected and serum separated 60 min later. Growth inhibition of serially diluted serum on H37Rv was tested with Alamar Blue assay. Vehicle, 0.5% CMC; INH, isoniazid at 10 mg/kg; AB-1, AB-1 at 100 mg/kg.
