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Reporter gene assay for FXR activation. Application of increasing concentrations (10 nM–100 μM) of the virtual hits 19 (A) and 20 (B), respectively, leads to dose dependent signal increase. FXR activity is expressed as fold difference of relative luciferase units (RLU) represented by mean values ± SEM resulting from triplicate determinations of three independent experiments (∗P <0.05, ∗∗P <0.01).
