Table 1.
Pre-MI | Post-MI | Post-Injection | 8 Weeks after MI | 8 Weeks after MI with Dobutamine | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Control | Treatment | Control | Treatment | Control | Treatment | Control | Treatment | Control | Treatment | |
Echocardiographic Data | ||||||||||
| ||||||||||
ESV (ml) | 27.5±1.7 | 25.2±1.2 | 43.8±2.6 | 43.6±2.1 | 44.6±2.9 | 41.7±2.4 | 80.3±6.9 | 60.8±4.3* | 42.1±7.4 | 32.5±3.1* |
EDV (ml) | 49.4±1.5 | 48.9±2.5 | 66.9±3.4 | 67.9±2.0 | 66.0±3.5 | 64.9±2.7 | 110.6±8.4 | 87.2±4.0* | 60.6±9.3 | 50.3±4.3* |
EF (%) | 44.3±2.9 | 47.9±2.0 | 34.6±1.3 | 36.0±1.9 | 34.5±1.4 | 35.5±1.7 | 27.6±1.3 | 31.0±2.6* | 31.4±1.2 | 36.0±2.5* |
Infarct Length (cm) | -- | -- | 7.2±0.3 | 7.1±0.3 | 7.1±0.3 | 6.8±0.4 | 9.3±0.6 | 8.0±0.2* | 9.5±0.6 | 8.2±0.5* |
| ||||||||||
Hemodynamic Data | ||||||||||
| ||||||||||
Heart Rate | 90.9±2.3 | 92.3±4.3 | 102.2±3.8 | 103.0±4.1 | 104.2±4.7 | 102.0±4.6 | 91.7±5.3 | 92.9±3.3 | 199.3±7.6 | 220.2±3.2* |
Systolic LV Pressure (mmHg) | 101.3±5.3 | 103.3±1.5 | 100.3±4.4 | 99.3±3.6 | 98.3±2.7 | 99.3±8.0 | 96.3±7.6 | 98.3±4.7 | 87.3±7.7 | 91.3±3.7 |
Diastolic LV Pressure (mmHg) | 5±2 | 4±1.5 | 14.0±4.2 | 16.1±3.3 | 14.7±6.2 | 15.1±5.3 | 12.3±1.1 | 9.8±2.4 | 9.6±3.7 | 7.7±2.9 |
Cardiac Output | 4.4±0.2 | 4.7±0.4 | 2.9±0.6 | 2.9±0.7 | 2.8±0.4 | 3.1±0.2 | 2.7±0.1 | 4.2±0.2* | 4.8±0.9 | 6.0±0.3* |
CVP | 13.4±3.1 | 12.6±2.4 | 15±2.9 | 15±4.9 | 15±4.9 | 12±3.9 | 14.5±1.3 | 13.4±1.1 | 12.7±0.8 | 11.5±1.0 |
Average values ± standard error of the mean
p<0.05 vs. Control