Table 1.
Published cases of neoplasia in buried metaplasia
| Report first author | Patient age (years) | Endoscopic therapy | Baseline degree of neoplasia | Location of buried neoplasia | Degree of buried neoplasia | Time after ablation | Outcome |
|---|---|---|---|---|---|---|---|
| Shand et al. (5) | 67 | APC | LGD | NR | Metastases (liver) | 4 months | Unresectable tumor |
| Van Laethem et al. (6) | 68 | APC | No dysplasia | Squamo-columnar junction | TisN0 | 18 months | EMR, no recurrence at 12 months |
| Mino-Kenudson et al. (8) | NR | PDT | HGD/superficial adenocarcinoma | Variable | IA (2) IMC (4) HGD (6) LGD (1) |
2–25 months | 8 of 13 responded to another session of endoscopic therapy |
| Overholt et al. (9) | NR | PDT | HGD | Near NSQ-columnar junction in 2 of 3 patients | NR | 6 months, 46 months, 52 months | 1—retreated, no recurrence at 3 years 1—retreated, no recurrence at 1 year 1—brachytherapy, local recurrence at 6 months |
| Ban et al. (10) | NR | PDT | HGD/superficial adenocarcinoma | NR | IA—3 IMC—2 HGD—7 |
NR | NR |
| Ragunath et al. (11) | 55 | PDT | LGD | NR | T1N0 | 4 months | Esophagectomy |
| Overholt et al. (12) | NR | PDT | HGD | Center of treated area | IMC | 6 months | Repeat PDT; no recurrence at 24 months |
| Bonavina et al. (13) | NR | Laser ablation | No dysplasia | NR | T1N0 | 6 months | Esophagectomy |
| Wolfsen et al. (14) | NR | PDT | T1N0M0 adenocarcinoma | At site of prior lesion | T1N0 | NR | Esophagectomy |
APC, argon plasma coagulation; EMR, endoscopic mucosal resection; HGD, high-grade dysplasia; IA, invasive adenocarcinoma; IMC, intramucosal carcinoma; LGD, low-grade dysplasia; NR, not reported; NSQ, neosquamous; PDT, photodynamic therapy.