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. Author manuscript; available in PMC: 2012 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Oct 13;21(24):7426–7430. doi: 10.1016/j.bmcl.2011.10.011

Figure 1.

Figure 1

Growth inhibition of normal human cells in culture by polyamine and aminothiol molecules. Structures of (A) first generation synthetic polyamines. (B) first generation “thiolated polyamines” and the next generation aminothiol, PrC-210. (C) Molecules were added at indicated concentrations to log phase, growing cultures of diploid human fibroblasts, and cell numbers were measured 4 days later. (D) Growth inhibition is directly related to the number of [NH-(CH2)] segments present in the polyamine or aminothiol molecule. (E) Olefinic core – common to polyamine and polyamine-thiol series.