Skip to main content
. Author manuscript; available in PMC: 2012 Dec 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Oct 13;21(24):7426–7430. doi: 10.1016/j.bmcl.2011.10.011

Scheme 2.

Scheme 2

Reagents and conditions: (a) 2 eq. potassium phthalimide, DMF; (b) 1. NH2NH2-H2O, 2. HCl; (c) NaOH, mesitylenesulfonyl chloride; (d) 1. BH3-THF, 2. H2O2, NaOH; (e) MsCl, Et3N, CH2Cl2; (f) KSAc, DMF; (g) HBr, PhOH, HOAc, CH2Cl2; (h) K2CO3 (aq); (i) HCl (aq), 2-mercaptoethanol; recrystallize.