Table 1.
Summary of DNA Glycosylases
| Gene Symbol | Gene | Type of Glycosylase | Substrates |
|---|---|---|---|
| OGG1 | 8-oxoguanine DNA glycosylase | bifunctional | 8-oxoG:C/G/T; 8-oxoG-FapyG; |
| MUTYH | mutY homolog (E. coli) | monofunctional | 8-oxoG:A |
| TDG | thymine-DNA glycosylase | monofunctional | T:G; ethenoC:G |
| MBD4 | methyl-CpG binding domain protein 4 | monofunctional | T:G; 5-meCpG:TpG; O6-meG:T |
| UNG | uracil-DNA glycosylase | monofunctional | uracil |
| SMUG1 | single-strand-selective monofunctional uracil-DNA glycosylase 1 | monofunctional | U:G; 5-hydroxymethyluracil; 5-formyluracil |
| NTHL1 (NTH1) | nth endonuclease III-like 1 (E. coli) | bifunctional | oxidized pyrimidines, formamidopyrimidines, 5-formyluracil; incises AP sites |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | bifunctional; APE-independent | oxidized pyrimidines, formamidopyrimidines, thymine glycol, hydantoin, guanidinohydantoin, spiroiminodihydantoin; removes lesions in single-stranded, bubble, and forked DNA structures |
| NEIL2 | nei endonuclease VIII-like 2 (E. coli) | bifunctional; APE-independent | oxidized pyrimidiines; removes lesions in single-stranded and bubble DNA structures |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | bifunctional | hydantoin, guanidinohydantoin, spiroiminodihydantoin; removes lesions in single-stranded and bubble DNA structures |
| AAG (MPG) | N-methylpurine-DNA glycosylase | monofunctional | methylated bases (i.e. 7-meG, 3-meA); 1-N6-etheno-A, 1-N2-ethenoG, uracil |