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. 2012 Jan 10;7(1):e29579. doi: 10.1371/journal.pone.0029579

Figure 2. Genetic factors that influence airway responsiveness.

Figure 2

A) Heat map showing lod scores derived from two-QTL (upper left half) and one-QTL (lower right half) analyses for linkage to airway responsiveness in 115 F2 mice and one mouse of each parental strain (using mean values of airway responsiveness for A/J and C57Bl/6J mice, as calculated in Figure 1). B) Genotypes at markers rs13480853 on chromosome 11 and rs6358426 on chromosome 18 interact significantly to determine native airway responsiveness. Mice with homozygous A/J genotype at both loci exhibit significantly greater AR (about double) than mice with any other sets of genotypes. Mean ± SEM shown. AA - homozygous A/J genotype; AB - heterozygous A/J+C57BL/6J genotype; BB - homozygous C57BL/6J genotype.