Figure 2. Sequence alignments surrounding six of the treatment response associated SNPs.
Alignment comparing 50 bp sequence surrounding SNP locations in IL28B reference sequence from NCBI genome build 37 and the corresponding reverse complement regions of IL28A reference sequence (RC ref). SNP identifiers (color coded to match Figure 1) and their respective alleles are shown. Ancestral alleles were obtained from dbSNP, except for those indicated by +; in these cases, the allele was based upon alignment of gorilla, chimpanzee, macaque and orangutan sequences. SNP locations on each alignment are highlighted in red. The asterisk denotes sequence identity.