Table 1. Summary of Sex, Age and Minor Allele Frequencies by Cohort.
Cohort | ||||||||
Variable | NSHD | ELSA | HCS | HAS | Boyd Orr | CaPS | LBC1921 | Total |
Number of participants | 2618 | 5515 | 2902 | 551 | 397 | 867 | 514 | 13364 |
Male, % | 50 | 46 | 53 | 59 | 45 | 100 | 41 | 52 |
Age* in years, median (range) | 53 | 65 (52–90+) | 66 (59–73) | 67 (63–73) | 70 (64–82) | 73 (65–83) | 79 (77–80) | 65 (52–90+) |
Minor Allele Frequencies | ||||||||
rs35767 (IGF1) | 0.16 | 0.15 | 0.15 | 0.16 | 0.16 | 0.16 | 0.14 | 0.15 |
rs7127900 (IGF2) | 0.18 | 0.18 | 0.20 | 0.21 | 0.19 | 0.17 | 0.19 | 0.19 |
rs2854744 (IGFBP3) | 0.47 | 0.45 | 0.46 | 0.45 | 0.42 | 0.46 | 0.42 | 0.45 |
rs2943641 (IRS1) | 0.36 | 0.35 | 0.35 | 0.36 | 0.38 | 0.35 | 0.35 | 0.35 |
rs2665802 (GH1) | 0.41 | 0.40 | 0.41 | 0.41 | 0.39 | 0.40 | 0.41 | 0.41 |
d3GHR | 0.26 | 0.27 | 0.27 | 0.24 | 0.27 | 0.28 | 0.26 | 0.27 |
Numbers of participants represent those with available data for at least one anthropometric or physical capability phenotype and at least one genotype.
*Age at phase from which the majority of variables are taken, i.e. Boyd Orr: III; CaPS: V; ELSA: II; HAS: I; HCS: I; LBC1921: I; NSHD: 1999 Collection. CaPS: Caerphilly Prospective Study; ELSA: English Longitudinal Study of Ageing; HAS: Hertfordshire Ageing Study; HCS: Hertfordshire Cohort Study; NSHD: National Survey of Health and Development.