Table 1. Karyotypic formulas of the subclones (A to H) presently found in HH-16 cl.2/1 cell line.

Subclone	Karyotypic formulas
A	38∼42,X,-X,t(3;11)(p12;p12),der(7)t(1;7)(q51;q36),del(13)(p13),der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(19)t(4;19)(q31;p11)t(6;19)(q14;q12) [6]
B	35∼42,X,-X,t(3;11)(p12;p12),der(7)t(1;7)(q51;q36),del(13)(p13),der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(19)t(6;19)(q14;q12) [14]
C	30∼41, X,-X,t(3;11)(p12;p12),der(4;15)(q10;p10),del(13)(p13),der(15)del(15)(p11)t(1;15)(q12;q24), der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2,der(19)t(6;19)(q14;q12) [9]
D	30∼41,X,-X,t(3;11)(p12;p12),der(4;15)(q10;p10),del(13)(p13),der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(19)t(6;19)(q14;q12) [14]
E	30∼42,X,-X,t(3;11)(p12;p12),del(13)(p13),der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(19)t(6;19)(q14;q12) [11]
F	39∼41,X,-X,t(3;11)(p12;p12),del(13)(p13), der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(18)t(1;18)(q11;q12.3),der(19)t(6;19)(q14;q12) [3]
G	38∼42,X,-X,t(3;11)(p12;p12),del(13)(p13),der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(18;19)t(18;19)(p10,q10)t(6;19)(q14;q12),−18 [4]
H	42,X,-X,t(3;11)(p12;p12),del(13)(p13),der(15)inv(15)(p14∼p16q23∼q25)inv(15)(p12∼p14q22∼q23)×2, der(19)t(6;19)(q14;q12),+1 [3]

The karyotype formulas correspond to the different subclones identified in HH-16 cl.2/1 cell line allowing the identification of ancestral chromosome rearrangements and to deduce the hypothetic clonal evolution shown in Figure 5.