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. 2012 Jan 10;6(1):e1466. doi: 10.1371/journal.pntd.0001466

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Paris et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Serial sections at the dermal-epidermal border, demonstrate that APCs are the dominant cell type adjacent to the central necrotic zone of the eschar. Immunophenotyping by MHC class II receptor for APCs (Panel A: HLADR), macrophages (B: CD68) and DCs (C: DC-SIGN, D: FXIIIa, G: S100 and H: LSECtin), neutrophils (E: CD15) and lymphocytes (F: CD4). The proportion of dendritic cells was higher in the dermal-epidermal border zone, than in the deeper dermis. Subepidermal vacuolization is prominent. Patient TM2663, magnification ×400, counterstained with haematoxylin, peroxidase immunostaining in brown.