. Author manuscript; available in PMC: 2013 Jan 10.

Published in final edited form as: Biochemistry. 2011 Dec 20;51(1):63–73. doi: 10.1021/bi201570a

Table 3.

Binding of PNA and GPNA (L-series) to ribosomal A-site model RNA hairpins (Figure 7).^a

Entry	PNA	Sequence	M. Tuberculosis (HRP6)	H. Sapiens (HRP5)
1	PNA10	NH₂-CCCTGCTT	1.2 (1.7)	0.4 (2.0)
2	GPNA10	NH₂-CCCT^L-ArgT^L-ArgGCT	0.5 (2.9)	2.8 (5.0)
3	PNA11	NH₂-CCTGCTT	0.2 (1.1)	0.04 (0.9)
4	PNA12	NH₂-CTGCTT	0.2 (1.6)	0.06 (0.9)
5	GPNA12	NH₂-CT^L-ArgGCTT	0.4 (1.8)	0.8 (2.1)
6	GPNA13	NH₂-CT^L-ArgGCT^L-ArgT	2.9 (8.0)	8.1 (8.8)
7	PNA13	NH₂-CCCTPCTT	1.5 (1.1)	NB^b
8	PNA14	NH₂-CCCTP_exCTT	2.0 (1.1)	NB^b

Average association constants K_a × 10⁶ M⁻¹ in sodium acetate buffer, pH 5.5; binding order is given in parenthesis.

No binding, K_a < 10³ M⁻¹.