Table 1a.
Mean (±SD) of each measure by region for each group: ℓ1-regularized QSM results using phase-guided ROIs and FDRI-guided ROIs
| Region | ℓ1-regularized QSM (ppm), phase-guided ROIs | ℓ1-regularized QSM (ppm), FDRI-guided ROIs | ||||
|---|---|---|---|---|---|---|
| Young (N=11) | Elderly (N=12) | t(elderly>young) | Young (N=11) | Elderly (N=12) | t(elderly>young) | |
| Frontal WM | 0.0367 (0.0187) | 0.02982 (0.0251) |
t= −0.7505a p=0.2307 |
0.0349 (0.0190) | 0.0275 (0.0194) |
t= −0.9182a p=0.1844 |
| Thalamus | 0.0464 (0.0230) | 0.0220 (0.0129) |
t= −2.1336a p=0.0224 |
0.0420 (0.0210) | 0.0208 (0.0317) |
t= −1.8805a p=0.0370 |
| Caudate | 0.0937 (0.0189) | 0.1033 (0.0274) |
t=0.9689 p=0.1718 |
0.0763 (0.0224) | 0.1038 (0.0356) |
t=2.1970 p=0.0197 |
| Putamen | 0.0779 (0.0188) | 0.1233 (0.0343) |
t=3.8807 p=0.0004 |
0.0683 (0.0205) | 0.1134 (0.0369) |
t=3.5777 p=0.0009 |
| Globus Pallidus | 0.1224 (0.0200) | 0.1472 (0.0261) |
t=2.5420 p=0.0095 |
0.1422 (0.0172) | 0.1961 (0.0318) |
t=4.9807 p=0.0001 |
| Substantia Nigra | 0.0820 (0.0299) | 0.1113 (0.0372) |
t=2.0712 p=0.0254 |
0.1045 (0.0426) | 0.1524 (0.0331) |
t=3.0319 p=0.0031 |
| Red Nucleus | 0.0933 (0.0379) | 0.1473 (0.0413) |
t=3.2568 p=0.0019 |
0.0927 (0.0395) | 0.1435 (0.0458) |
t=2.8404 p=0.0049 |
| Dentate Nucleus | 0.0693 (0.0151) | 0.0595 (0.0292) |
t= −1.0000a p=0.1643 |
0.0544 (0.0174) | 0.0487 (0.0225) |
t= −0.6703a p=0.2550 |
p-values are 2-tailed. Numbers in bold indicate significant differences, family-wise Bonferroni corrected based on one-tailed directional hypotheses, requiring p ≤.0.0125 for 8 comparisons.
a
Negative t values indicate a group difference with the elderly having less iron than the young.